Methylene Blue Powder Reagent 25g

Methylene Blue Powder Reagent 25g

Methylene Blue Powder Reagent 25g is a high quality chemical with 98% purity. As a leading manufacturer we test and formulate each batch to the highest standard.

Please refer to the safety data sheet for information on stability, storage conditions, protective measures and disposal of the methylene blue solution.

Methylene Blue Powder Reagent is used in many scientific and medical applications. Its versatility makes it an essential tool in laboratories, research institutions and pharmaceutical companies. This product is for professionals who need an accurate and reliable reagent for their experiments and analysis. The use of methylene blue implicated as dye, especially methylene, in medical applications such as lymphatic mapping and pharmacokinetics highlights its importance in absorption, distribution and excretion studies, safe for pregnant women.

With 98% purity, itgives you accurate and consistent results in many applications. Whether you are doing medical diagnostics, microbiology studies or staining tissues in histopathology this product gives you the reliability and precision you need. Methylene blue is also used for blue staining in molecular biology techniques, so it’s a great tool for educational setting since it’s non toxic and more effective than SYBR Green and ethidium bromide.

The 25g packaging of Methylene Blue Powder Reagent is enough for your laboratory needs, it’s convenient and cost effective. The resealable container ensures the product longevity and integrity, so you have peace of mind and value for your money.

This item puts the safety of the health care professional who use our products first. This Methylene Powder Reagent is manufactured under strict quality control, meets the highest safety standard. We have thorough testing and quality assurance process in place so you can trust the consistency and reliability of this product.

Whether you are a scientist or a student doing experiments Methylene Blue Powder Reagent 25g is the best for your scientific and medical needs. Its high purity, enough supply and convenient, it’s a trusted tool in laboratories worldwide.

Choose MB-0025 for your research, analysis and diagnostic needs and experience the best quality and performance of this product.

Overview

Methylene blue also known as methylthioninium chloride is implicated as a versatile compound used as a dye and a medication. Its medical application is in the treatment of methemoglobinemia, a condition where hemoglobin is unable to carry oxygen, usually given as a methylene injection. Beyond that methylene is used as an antidote for certain type of poisoning, a diagnostic agent and a treatment for certain medical condition. Many case studies have documented patients who received methylene for life threatening condition like refractory anaphylaxis and septic shock, showed immediate symptom relief and potential side effects. Its multiple uses make it a valuable tool in both clinical and laboratory setting.

Pharmacology of Methylene Blue Injection

Mechanism of Action

Methylene blue reduces the oxidized form of hemoglobin (Fe3+) to its normal form (Fe2+) so the red blood cells can carry oxygen again. This is useful in treating methemoglobinemia where the blood cells are impaired in their oxygen carrying capacity. Methylene staining is used for visualizing nucleic acids in agarose gels and on filter membranes. Methylene also inhibits endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and guanylate cyclase, causing vasoconstriction of blood vessels. This is useful in managing vasoplegic syndrome. Methylene is also used in the treatment of malaria by reducing the resistance of Plasmodium falciparum to chloroquine and inhibiting the enzyme glutathione reductase so the antimalarial treatment is more effective.

Methylene Blue Uses

Methylene blue is a powerful reducing agent that converts the oxidized form of hemoglobin (Fe3+) back to its reduced form (Fe2+). This is important as it restores the ability of red blood cells to carry oxygen again which is useful in treating methemoglobinemia. Beyond that methylene blue is a competitive inhibitor of guanylate cyclase, blocks the vasodilatory action of nitric oxide. This is useful in managing vasoplegic syndrome. Methylene blue acts in the treatment of various condition like malaria, ifosfamide-induced encephalopathy and fatal serotonin toxicity. Its multiple uses make it a valuable tool in both clinical and laboratory setting.

Clinical Use of Methylene Blue Treatment

Indications for Ifosfamide Induced Encephalopathy

Methylene blue is indicated for methemoglobinemia, a condition where there is an abnormal amount of methemoglobin in the blood which impairs the blood’s ability to carry oxygen. Methylene blue injection is also used for vasoplegic syndrome, a condition of severe vasodilation and low blood pressure often seen after cardiac surgery. Methylene blue is also effective against Plasmodium falciparum, the parasite that causes malaria and is used to treat ifosfamide-induced encephalopathy, a rare but serious side effect of the chemotherapy drug ifosfamide. Beyond these therapeutic uses, methylene blue is used as a diagnostic agent for sentinel lymph node mapping during breast procedures and parathyroid gland mapping during parathyroidectomies to help identify these critical structures.

Dose and Administration

Methylene blue is given via intravenous injection to ensure rapid effect. Dose and route of administration may vary depending on the condition being treated. For example in methemoglobinemia, 1 mg/kg of 1% solution is given over 5-30 minutes. For lymph node mapping 2-5 mL of 1% solution is given intraparenchymal. These specific dosages ensure that the treatment is both effective and safe for each condition.

Methylene Blue Treatment

Methylene blue is used to treat methemoglobinemia where the red blood cells ability to carry oxygen is severely impaired. By restoring the normal function of hemoglobin methylene blue relieves the symptoms of this condition. Methylene blue is also used to treat other serious condition like malaria, ifosfamide-induced encephalopathy and potentially fatal serotonin toxicity. Clinical studies have shown that methylene blue reduces mortality in methemoglobinemia and has been used to treat various other condition, hence its importance in modern medicine.

Adverse Effects: Fatal Serotonin Toxicity

Methylene blue can cause several side effects including blue-green discoloration of urine and limb pain after IV administration. One of the serious side effects of methylene blue is serotonin syndrome, a potentially fatal condition that occurs when combined with other serotonergic drugs and causes serotonin toxicity. Other side effects include central nervous system symptoms like dizziness, confusion and headaches in adults. In neonates methylene blue has caused hyperbilirubinemia, respiratory depression, pulmonary edema, phototoxicity and hemolytic anemia. These side effects emphasize the need for close monitoring and proper dosing when using methylene blue in clinical practice.

Contraindications

Methylene blue is contraindicated in patients who have had hypersensitivity or anaphylaxis to the drug in the past. It is also contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency as it can cause hemolytic anemia. Pregnant women should avoid methylene blue as it can harm the unborn baby. These contraindications emphasize the need for thorough patient evaluation before giving methylene blue.

Monitoring

Close monitoring is necessary for patients taking methylene blue to ensure effectiveness and safety of treatment. Blood tests may be required to detect any adverse effects and to monitor the patient’s response to treatment. Continuous medical supervision is crucial to prevent fatal serotonin toxicity and serotonin syndrome especially when methylene blue is given with other serotonergic drugs. This close monitoring will help minimize the risks and achieve better outcome for the patient.